The Molecular Switch : (Record no. 81479)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 07002cam a2200649 i 4500 |
| 001 - CONTROL NUMBER | |
| control field | on1154518403 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OCoLC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220908100213.0 |
| 006 - FIXED-LENGTH DATA ELEMENTS--ADDITIONAL MATERIAL CHARACTERISTICS | |
| fixed length control field | m o d |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr cnu---unuuu |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200530s2020 nju o 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EBLCP |
| Language of cataloging | eng |
| Description conventions | rda |
| -- | pn |
| Transcribing agency | EBLCP |
| Modifying agency | UKAHL |
| -- | JSTOR |
| -- | YDXIT |
| -- | DEGRU |
| -- | OCLCF |
| -- | NOC |
| -- | YDX |
| -- | N$T |
| -- | OCLCQ |
| -- | OCLCO |
| -- | IEEEE |
| -- | OCLCO |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 0691200254 |
| Qualifying information | (electronic book) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9780691200255 |
| Qualifying information | (electronic bk.) |
| 029 1# - OTHER SYSTEM CONTROL NUMBER (OCLC) | |
| OCLC library identifier | AU@ |
| System control number | 000067958117 |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (OCoLC)1154518403 |
| 037 ## - SOURCE OF ACQUISITION | |
| Stock number | 22573/ctvx52qpb |
| Source of stock number/acquisition | JSTOR |
| 037 ## - SOURCE OF ACQUISITION | |
| Stock number | 9453430 |
| Source of stock number/acquisition | IEEE |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | QP517.C45 |
| Item number | P55 2020 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 571.74 |
| Edition number | 23 |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | MAIN |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Phillips, Rob, |
| Relator term | author. |
| 9 (RLIN) | 65547 |
| 245 14 - TITLE STATEMENT | |
| Title | The Molecular Switch : |
| Remainder of title | Signaling and Allostery / |
| Statement of responsibility, etc. | Rob Phillips ; illustrated by Nigel Orme. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Princeton : |
| Name of producer, publisher, distributor, manufacturer | Princeton University Press, |
| Date of production, publication, distribution, manufacture, or copyright notice | [2020] |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource (437 pages) |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 490 0# - SERIES STATEMENT | |
| Series statement | Studies in physical biology |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Cover -- Contents -- Preface -- PART I: THE MAKING OF MOLECULAR SWITCHES -- 1. It's An Allosteric World -- 1.1 The Second Secret of Life -- 1.2 The Broad Reach of the Allostery Concept -- 1.2.1 Sculpting Biochemistry via Allostery -- 1.2.2 One- and Two-Component Signal Transduction and the Two-State Philosophy -- 1.3 Reasoning about Feedback: The Rise of Allostery -- 1.3.1 The Puzzle -- 1.3.2 The Resolution of the Molecular Feedback Puzzle -- 1.3.3 Finding the Allosterome -- 1.4 Mathematicizing the Two-State Paradigm -- 1.4.1 Transcendent Concepts in Physics |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 1.4.2 One Equation to Rule Them All -- 1.5 Beyond the MWC Two-State Concept -- 1.5.1 Molecular Agnosticism: MWC versus KNF versus Eigen -- 1.6 On BeingWrong -- 1.7 Summary -- 1.8 Further Reading -- 1.9 References -- 2. The Allosterician's Toolkit -- 2.1 A Mathematical Microscope: Statistical Mechanics Preliminaries -- 2.1.1 Microstates -- 2.1.2 The Fundamental Law of Statistical Mechanics -- 2.1.3 The Dimensionless Numbers of Thermal Physics -- 2.1.4 Boltzmann and Probabilities -- 2.2 Case Study in Statistical Mechanics: Ligand-Receptor Binding |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 2.2.1 Ligand Binding and the Lattice Model of Solutions -- 2.3 Conceptual Tools of the Trade: Free Energy and Entropy -- 2.3.1 Resetting Our Zero of Energy Using the Chemical Potential -- 2.4 The MWC Concept in Statistical Mechanical Language -- 2.5 Cooperativity and Allostery -- 2.5.1 Cooperativity and Hill Functions -- 2.5.2 Cooperativity in the MWC Model -- 2.6 Internal Degrees of Freedom and Ensemble Allostery -- 2.7 Beyond Equilibrium -- 2.8 Summary -- 2.9 Further Reading -- 2.10 References -- PART II: THE LONG REACH OF ALLOSTERY -- 3. Signaling at the Cell Membrane: Ion Channels |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 3.1 How Cells Talk to the World -- 3.2 Biological Processes and Ion Channels -- 3.3 Ligand-Gated Channels -- 3.4 Statistical Mechanics of the MWC Channel -- 3.5 Data Collapse, Natural Variables, and the Bohr Effect -- 3.5.1 Data Collapse and the Ion-Channel Bohr Effect -- 3.6 Rate Equation Description of Channel Gating -- 3.7 Cyclic Nucleotide-Gated Channels -- 3.8 Beyond the MWC Model in Ion Channelology -- 3.8.1 Conductance Substates and Conformational Kinetics -- 3.8.2 The Koshland-N�emethy-Filmer Model Revealed -- 3.8.3 Kinetic Proliferation -- 3.8.4 The Question of Inactivation -- 3.9 Summary |
| 505 8# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | 3.10 Further Reading -- 3.11 References -- 4. How Bacteria Navigate the World around Them -- 4.1 Bacterial Information Processing -- 4.1.1 Engelmann's Experiment and Bacterial Aerotaxis -- 4.1.2 Love Thy Neighbors: Signaling between Bacteria -- 4.2 Bacterial Chemotaxis -- 4.2.1 The Chemotaxis Phenomenon -- 4.2.2 Wiring Up Chemotaxis through Molecular Switching -- 4.3 MWC Models of Chemotactic Response -- 4.3.1 MWC Model of Chemotaxis Receptor Clusters -- 4.3.2 Heterogenous Clustering -- 4.3.3 Putting It All Together by Averaging -- 4.4 The Amazing Phenomenon of Physiological Adaptation |
| 500 ## - GENERAL NOTE | |
| General note | 4.4.1 Adaptation by Hand |
| 588 0# - SOURCE OF DESCRIPTION NOTE | |
| Source of description note | Online resource; title from digital title page (viewed on September 16, 2020). |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | A signature feature of living organisms is their ability to carry out purposeful actions by taking stock of the world around them. To that end, cells have an arsenal of signaling molecules linked together in signaling pathways, which switch between inactive and active conformations. The Molecular Switch articulates a biophysical perspective on signaling, showing how allostery--a powerful explanation of how molecules function across all biological domains--can be reformulated using equilibrium statistical mechanics, applied to diverse biological systems exhibiting switching behaviors, and successfully unify seemingly unrelated phenomena. Rob Phillips weaves together allostery and statistical mechanics via a series of biological vignettes, each of which showcases an important biological question and accompanying physical analysis. Beginning with the study of ligand-gated ion channels and their role in problems ranging from muscle action to vision, Phillips then undertakes increasingly sophisticated case studies, from bacterial chemotaxis and quorum sensing to hemoglobin and its role in mammalian physiology. He looks at G-protein coupled receptors as well as the role of allosteric molecules in gene regulation. Phillips concludes by surveying problems in biological fidelity and offering a speculative chapter on the relationship between allostery and biological Maxwell demons. Appropriate for graduate students and researchers in biophysics, physics, engineering, biology, and neuroscience, The Molecular Switch presents a unified, quantitative model for describing biological signaling phenomena. |
| 590 ## - LOCAL NOTE (RLIN) | |
| Local note | IEEE |
| Provenance (VM) [OBSOLETE] | IEEE Xplore Princeton University Press eBooks Library |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cellular signal transduction. |
| 9 (RLIN) | 14068 |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cellular control mechanisms. |
| 9 (RLIN) | 65548 |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Signal Transduction |
| 9 (RLIN) | 65549 |
| 650 #6 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Transduction du signal cellulaire. |
| 9 (RLIN) | 65550 |
| 650 #6 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | R�egulation cellulaire. |
| 9 (RLIN) | 65551 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | SCIENCE |
| General subdivision | Life Sciences |
| -- | Biophysics. |
| Source of heading or term | bisacsh |
| 9 (RLIN) | 65552 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cellular control mechanisms |
| Source of heading or term | fast |
| Authority record control number or standard number | (OCoLC)fst00850278 |
| 9 (RLIN) | 65548 |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cellular signal transduction |
| Source of heading or term | fast |
| Authority record control number or standard number | (OCoLC)fst00850288 |
| 9 (RLIN) | 14068 |
| 655 #4 - INDEX TERM--GENRE/FORM | |
| Genre/form data or focus term | Electronic books. |
| 9 (RLIN) | 3294 |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Print version: |
| Main entry heading | Phillips, Rob. |
| Title | Molecular Switch : Signaling and Allostery. |
| Place, publisher, and date of publication | Princeton : Princeton University Press, �2020 |
| International Standard Book Number | 9780691200248 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://ieeexplore.ieee.org/servlet/opac?bknumber=9453430">https://ieeexplore.ieee.org/servlet/opac?bknumber=9453430</a> |
| 938 ## - | |
| -- | Askews and Holts Library Services |
| -- | ASKH |
| -- | AH37414671 |
| 938 ## - | |
| -- | De Gruyter |
| -- | DEGR |
| -- | 9780691200255 |
| 938 ## - | |
| -- | ProQuest Ebook Central |
| -- | EBLB |
| -- | EBL6195824 |
| 938 ## - | |
| -- | EBSCOhost |
| -- | EBSC |
| -- | 2377008 |
| 938 ## - | |
| -- | YBP Library Services |
| -- | YANK |
| -- | 16665712 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | eBooks |
| 994 ## - | |
| -- | 92 |
| -- | INTKS |
No items available.