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Front Cover; Smart Nanocontainers; Copyright; Contents; Contributors; Part I: Fundamentals; Chapter 1: Nanocontainer: An introduction; References; Chapter 2: Advanced spectroscopic technique for the study of nanocontainers: atomic force microscopy-infrared spectroscop ... ; 1. Introduction; 2. AFM-IR technology; 2.1. Development of AFM-IR; 2.2. Resonance-enhanced AFM-IR and tapping AFM-IR; 2.3. Analysis of AFM-IR measurements; 3. Applications of AFM-IR for the study of nanocontainers; 4. Conclusion; References; Chapter 3: Methods for synthesis of nanocontainers; 1. Introduction

2. Layer-by-layer technique3. Self-assembly; 4. Emulsion-based synthetic processes; 4.1. Miniemulsion polymerization; 4.2. Microemulsion; 4.3. Microemulsion mediated synthesis of silica-based nanomaterials; 5. The precipitation-based synthetic methods; 6. Ultrasonic techniques; 7. Convergent and divergent approach; References; Chapter 4: Nanoscale characterization of nanocarriers; 1. Introduction; 2. Nanoscale characterization; 2.1. Physical characterization; 2.1.1. Particle size; 2.1.2. Surface charge; 2.1.3. Drug release; 2.1.4. Stability; 2.2. Chemical characterization

2.2.1. Chemical composition2.2.2. Surface chemistry; 2.3. Biological evaluation; 2.3.1. In vitro; 2.3.1.1. Pyrogenicity; 2.3.1.2. Hemocompatibility test; 2.3.1.2.1. Hemolysis; 2.3.1.2.2. Thrombogenicity; 2.3.1.2.3. Complement activation system; 2.3.1.3. Protein adsorption; 2.3.1.4. Cell based evaluation; 2.3.1.4.1. 2D cell culture; 2.3.1.4.2. 3D cell culture; 2.3.2. In vivo evaluation; 2.3.2.1. Tumor model; 3. Challenges and future perspectives; 4. Regulatory concerns for nanoscale characterization; 5. Environmental risk and its considerations; 6. Concluding remarks; References

Chapter 5: Mechanism of loading and release in nanocontainers1. Introduction; 2. Encapsulation and entrapment mechanism; 2.1. Chemical loading/entrapment mechanism; 2.2. Physical entrapment; 2.2.1. Hydrogen-bonding; 2.2.2. Electrostatic interaction; 2.2.3. Hydrophobic interaction; 2.2.4. Vander Waals interaction; 3. Mechanisms of active compound release; 3.1. Delayed release; 3.2. Sustained release; 3.3. Controlled release; 3.3.1. Diffused controlled release; 3.3.2. Solvent-controlled release; 3.4. Extended release; 3.5. Exact places targeting release; 4. Conclusion; References

Further readingChapter 6: Mathematical modeling and simulation; 1. Introduction; 2. Modeling and simulation methods; 3. Excerpted researches in modeling and simulation of smart nanocontainers; 4. Outlook; References; Further reading; Part II: Application in food products; Chapter 7: Nanocontainers for food safety; 1. Introduction; 2. Polymeric nanocontainers; 2.1. Metal/metal oxide loaded nanocontainers; 2.1.1. Food safety applications; 2.1.2. Determination of contaminants; 2.2. Nanofiber as nanocontainer; 2.2.1. Nanocontainers into nanofibers; 2.2.2. Molecular complexes into nanofibers

2.2.3. Nanofibers based nanosensors

Includes bibliographical references and index.

Smart Nanocontainers explores the fundamental concepts and emerging applications of nanocontainers in biomedicine, pharmaceuticals and smart materials. In pharmaceuticals, nanocontainers have advantages over their micro-counterparts, including more efficient drug detoxification, higher intracellular uptake, better stability, less side effects and higher biocompatibility with tissue and cells. In materials science, such as coating technology, they help by making coatings smarter, stronger and more durable. This important reference will help anyone who wants to learn more on how nanocontainers are used to provide the controlled release of active agents, including their applications in smart coatings, corrosion, drug delivery, diagnosis, agri-food and gas storage.