Agile and Migration -- Migration from Ionic to Android: Implications -- The migration journey towards microservices -- Migrating from a Centralized Data Warehouse to a Decentralized Data Platform Architecture -- How Do Agile Teams Manage Impediments? -- Keeping the momentum: Driving continuous improvement after the large-scale agile transformation -- Requirements -- How Do Practitioners Interpret Conditionals in Requirements? -- Situation- and Domain-specific Composition and Enactment of Business Model Development Methods -- Using a data-driven context model to support the elicitation of context-aware functionalities - a controlled experiment -- A Transformation Model for Excelling in Product Roadmapping in Dynamic and Uncertain Market Environments -- Introducing Traceability in GitHub for Medical Software Development -- Human Factors -- An Empirical Study on Personality Traits and Team Climate in a Smart-Working Development Context -- Searching for bellwether developers forcross-personalized defect prediction -- Using Machine Learning to Recognise Novice and Expert Developers -- Is knowledge the key? An experiment on debiasing architectural decision-making - a pilot study.-Communicating Cybersecurity Vulnerability Information: A Producer-Acquirer Case Study -- Software quality -- Analyzing SAFe Practices with respect to Quality Requirements: Findings from a Qualitative Study -- Capitalizing on Developer-Tester Communication - A Case Study -- Toward a Technical Debt Relationship with the Pivoting of Growth Phase Startups -- Towards a Common Testing Terminology for Software Engineering and Artificial Intelligence Experts -- Towards RegOps: A DevOps Pipeline for Medical Device Software.-.

This book constitutes the refereed proceedings of the 22nd International Conference on Product-Focused Software Process Improvement, PROFES 2021, held in Turin, Italy, in November 2021. Due to COVID-19 pandemic the conference was held as a hybrid event. The 20 revised papers, including 14 full papers, 3 short papers and 3 industry papers, presented were carefully reviewed and selected from 48 submissions. The papers cover a broad range of topics related to professional software development and process improvement driven by product and service quality needs. They are organized in the following topical sections: agile and migration, requirements, human factors, and software quality.