| 000 | 03401nam a2200409 i 4500 | ||
|---|---|---|---|
| 001 | 9780841299177 | ||
| 003 | DACS | ||
| 005 | 20230516163023.0 | ||
| 008 | 100319s2022 dcua ob 101 0 eng d | ||
| 020 |
_a9780841299177 _qelectronic |
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| 024 | 7 |
_a10.1021/acsinfocus.7e4008 _2doi |
|
| 035 | _a(CaBNVSL)slc00002391 | ||
| 040 |
_aNjRocCCS _beng _erda _cNjRocCCS |
||
| 050 | 4 |
_aR857.B54 _bB436 2022eb |
|
| 060 | 4 |
_aQT 34 _b.B436 2022eb |
|
| 082 | 0 | 4 |
_a610.28 _223 |
| 100 | 1 |
_aBender, Rachel, L., _eauthor. _uEmory University. _967797 |
|
| 245 | 0 | 0 |
_aMolecular force sensors / _cRachel L. Bender & Khalid Salaita. |
| 264 | 1 |
_aWashington, DC, USA : _bAmerican Chemical Society, _c2022. |
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| 300 |
_a1 online resource : _billustrations (some color). |
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| 336 |
_atext _2rdacontent |
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| 337 |
_acomputer _2rdamedia |
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| 338 |
_aonline resource _2rdacarrier |
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| 490 | 1 |
_aACS in focus, _x2691-8307 |
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| 504 | _aIncludes bibliographical references and index. | ||
| 505 | 0 | 0 |
_tIntroduction -- _tUsing Molecules as "Springs": Force-Extension Behavior of Macromolecules -- _tFörster Resonance Energy Transfer (FRET)Förster resonance energy transfer (FRET) -- _tGenetically Encoded Tension Sensorsgenetically encoded tension sensors (GETS) -- _tSynthetic Tension Sensorssynthetic tension sensors -- _tReadout Methodsreadout methods -- _tFuture Outlook -- _tCheck Your Understanding. |
| 520 |
_a"Molecular force sensors are a powerful tool for studying the mechanics of cells. These sensors not only provide information on the general mechanical behavior of cells but also can help elucidate the mechanical markers of disease formation and progression. For example, can we use cell mechanics as a biomarker to diagnose cancer? What are the mechanics associated with immune system function? Can cell mechanics be used to better understand the effect of drug treatments? The number of available questions in the field of mechanobiology is endless. After reading this e-book, you will be equipped with the information needed to begin designing your own molecular force sensors, and to begin answering the multitude of questions surrounding cell mechanobiology. Molecular force sensor development and the study of mechanotransduction are interdisciplinary, and publications in the field often involve teams of researchers from a range of scientific backgrounds. This work is intended to be accessible to advanced undergraduate students and graduate students and should appeal to individuals in the fields of chemistry, physics, engineering, and biology. Rather than providing an exhaustive list of equations or discussing every chemical and biological method used to describe and develop molecular force sensors, the authors include the principles most relevant to developing molecular force sensors and highlight some of the key literature demonstrating the use of such sensors in laboratory settings."-- _cProvided by publisher. |
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| 590 | _aAmerican Chemical Society, Molecular Force Sensors eBooks - 2022 Front Files. | ||
| 650 | 0 |
_aBiosensors. _97356 |
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| 650 | 0 |
_aCells _xMechanical properties _xMeasurement. _967530 |
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| 650 | 1 | 2 |
_aBiosensing Techniques. _97357 |
| 700 | 1 |
_aSalaita, Khalid, _eauthor. _uEmory University. _967798 |
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| 710 | 2 |
_aAmerican Chemical Society. _967532 |
|
| 830 | 0 |
_aACS in focus, _x2691-8307 _967799 |
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| 856 | 4 | _uhttp://dx.doi.org/10.1021/acsinfocus.7e4008 | |
| 942 | _cEBK | ||
| 999 |
_c82136 _d82136 |
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